Discovery: Disease mechanisms through genetics and multiple omics

Our discovery efforts include genome-wide association studies of COPD, interstitial lung abnormalities, mucus plugging, and related phenotypes through the International COPD Genetics Consortium, and through the Trans-Omics in Precision Medicine (TOPMed) consortium, and collaborations with the Tobin and Wain groups at the University of Leicester, the Hunninghake and Diaz groups at BWH, and the Manichaikul lab at UVA. We work to identify common and rare genetic risk factors using state-of-the-art methods and novel phenotypes (including imaging and machine learning). We have identified dozens of new genetic risk loci, effector genes and pathways through integrative omics, and shared risk factors between diseases.